Development and characterization of reverse genetics systems of feline infectious peritonitis virus for antiviral research

Abstract Feline infectious peritonitis Other Smoking Cessation Aids Products (FIP) is a lethal, immune-mediated disease in cats caused by feline infectious peritonitis virus (FIPV), a biotype of feline coronavirus (FCoV).In contrast to feline enteric coronavirus (FECV), which exclusively infects enterocytes and causes diarrhea, FIPV specifically ta

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Hematopoietic Stem and Progenitor Cells Are a Distinct HIV Reservoir that Contributes to Persistent Viremia in Suppressed Patients

Summary: Long-lived reservoirs of persistent HIV are a major barrier to a cure.CD4+ hematopoietic stem and progenitor cells (HSPCs) have the capacity for lifelong survival, self-renewal, and the generation of daughter cells.Recent evidence shows that they are also susceptible to HIV infection in vitro and in vivo.Whether HSPCs harbor infectious vir

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